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KMID : 0358419920350111599
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Korean Journal of Obstetrics and Gynecology
1992 Volume.35 No. 11 p.1599 ~ p.1606
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A Study of Low Dose Purified Follicle-Stimulating Hormone Supplemented with Gonadotropin Releasing Hormone Agonist in Women with Polycystic Ovarian Disease
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허의종/Hur EJ
이상훈/배도환/Lee SH/Pai DH
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Abstract
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Polycystic ovarian disease(PCOD) is characterized by a self-perpetuating cycle of chronic hormonal imbalance and is probably the most common endocrinological disorder amongst women during their reproductive years. The treatment of clomiphene citrate (CC)-resistant anovulation in infertile patients with PCOD remains a considerble clinical problem. Conventional gonadotropin therapy has been used for many years with variable success in pregnancy rate and is associated with a high risk of ovarian hyperstimulation and multiple pregnancy. Recently low-dose purified follicle-stimulating hormone(pFSH) or gonadotropin releasing hormone agonist (GnRH-a) come into use because they theoretically seem the ideal approach to ovulation induction of anovulatory women with elevated endogenous luteinizing hormone (LH) and are really safe and effective without ovarian hyperstimulation syndrome(OHSS). From November, 1991 to march, 1992 we undertook a randomized study to reduce the number of active follicles and lower the frequency of OHSS by administration of low-dose pFSH in the follicular phase until complete follicular maturation supplemented with GnRH-a in 8 patients suffering from CC-resistant of hMG+hCG-complicated PCOD. Our treatment resulted in a significant reduction in the number (2.6±1.3, mean±SD) of leading follicles and increase of cycle fecundity rate (60%,6/10 cycle) in comparison to other studies of administration of CC or human menopausal gonadotropin (hMG) supplemented with human chorionic gonadotropin (hCG). We think that this menagement can be an alternative method to induce ovulation with well-qualifed oocytes and lowering of OHSS, and to obtain relatively high pregnancy rate in women presenting with PCOD.
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KEYWORD
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